Identification of novel inhibitors for TNFα, TNFR1 and TNFα-TNFR1 complex using pharmacophore-based approaches

BACKGROUND: Tumor necrosis factor α (TNFα) is a multifunctional cytokine with a potent pro-inflammatory effect. It is a validated therapeutic target molecule for several disorders related to autoimmunity and inflammation. TNFα–TNF receptor-1 (TNFR1) signaling contributes to the pathological processe...

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Detalles Bibliográficos
Autores principales: Saddala, Madhu Sudhana, Huang, Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604280/
https://www.ncbi.nlm.nih.gov/pubmed/31266509
http://dx.doi.org/10.1186/s12967-019-1965-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604280/
https://www.ncbi.nlm.nih.gov/pubmed/31266509
http://dx.doi.org/10.1186/s12967-019-1965-5

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