MYC deregulates TET1 and TET2 expression to control global DNA (hydroxy)methylation and gene expression to maintain a neoplastic phenotype in T-ALL

BACKGROUND: While aberrant DNA methylation is a characteristic feature of tumor cells, our knowledge of how these DNA methylation patterns are established and maintained is limited. DNA methyltransferases and ten-eleven translocation methylcytosine dioxygenases (TETs) function has been found altered...

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Detalles Bibliográficos
Autores principales: Poole, Candace J., Lodh, Atul, Choi, Jeong-Hyeon, van Riggelen, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604319/
https://www.ncbi.nlm.nih.gov/pubmed/31266538
http://dx.doi.org/10.1186/s13072-019-0278-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604319/
https://www.ncbi.nlm.nih.gov/pubmed/31266538
http://dx.doi.org/10.1186/s13072-019-0278-5

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