Molecular determinants for agonist recognition and discrimination in P2X2 receptors

P2X receptors (P2XRs) are trimeric ligand-gated ion channels that open a cation-selective pore in response to ATP binding. P2XRs contribute to synaptic transmission and are involved in pain and inflammation, thus representing valuable drug targets. Recent crystal structures have confirmed the findin...

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Detalles Bibliográficos
Autores principales: Gasparri, Federica, Wengel, Jesper, Grutter, Thomas, Pless, Stephan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605687/
https://www.ncbi.nlm.nih.gov/pubmed/31126967
http://dx.doi.org/10.1085/jgp.201912347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605687/
https://www.ncbi.nlm.nih.gov/pubmed/31126967
http://dx.doi.org/10.1085/jgp.201912347

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