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Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin

Maintenance of a population of IL-17–committed γδ T cells in the dermis is important in promoting tissue immunity. However, the signals facilitating γδ T cell retention within the dermis remain poorly understood. Here, we find that sphingosine-1-phosphate receptor 2 (S1PR2) acts in a cell-intrinsic...

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Autores principales: Laidlaw, Brian J., Gray, Elizabeth E., Zhang, Yang, Ramírez-Valle, Francisco, Cyster, Jason G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605748/
https://www.ncbi.nlm.nih.gov/pubmed/31160320
http://dx.doi.org/10.1084/jem.20190114
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author Laidlaw, Brian J.
Gray, Elizabeth E.
Zhang, Yang
Ramírez-Valle, Francisco
Cyster, Jason G.
author_facet Laidlaw, Brian J.
Gray, Elizabeth E.
Zhang, Yang
Ramírez-Valle, Francisco
Cyster, Jason G.
author_sort Laidlaw, Brian J.
collection PubMed
description Maintenance of a population of IL-17–committed γδ T cells in the dermis is important in promoting tissue immunity. However, the signals facilitating γδ T cell retention within the dermis remain poorly understood. Here, we find that sphingosine-1-phosphate receptor 2 (S1PR2) acts in a cell-intrinsic manner to oppose γδ T cell migration from the dermis to the skin draining lymph node (dLN). Migration of dermal γδ T cells to the dLN under steady-state conditions occurs in an S1PR1-dependent manner. S1PR1 and CD69 are reciprocally expressed on dermal γδ T cells, with loss of CD69 associated with increased S1PR1 expression and enhanced migration to the dLN. γδ T cells lacking both S1PR2 and CD69 are impaired in their maintenance within the dermis. These findings provide a mechanism for how IL-17(+) γδ T cells establish residence within the dermis and identify a role for S1PR2 in restraining the egress of tissue-resident lymphocytes.
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spelling pubmed-66057482020-01-01 Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin Laidlaw, Brian J. Gray, Elizabeth E. Zhang, Yang Ramírez-Valle, Francisco Cyster, Jason G. J Exp Med Research Articles Maintenance of a population of IL-17–committed γδ T cells in the dermis is important in promoting tissue immunity. However, the signals facilitating γδ T cell retention within the dermis remain poorly understood. Here, we find that sphingosine-1-phosphate receptor 2 (S1PR2) acts in a cell-intrinsic manner to oppose γδ T cell migration from the dermis to the skin draining lymph node (dLN). Migration of dermal γδ T cells to the dLN under steady-state conditions occurs in an S1PR1-dependent manner. S1PR1 and CD69 are reciprocally expressed on dermal γδ T cells, with loss of CD69 associated with increased S1PR1 expression and enhanced migration to the dLN. γδ T cells lacking both S1PR2 and CD69 are impaired in their maintenance within the dermis. These findings provide a mechanism for how IL-17(+) γδ T cells establish residence within the dermis and identify a role for S1PR2 in restraining the egress of tissue-resident lymphocytes. Rockefeller University Press 2019-07-01 2019-06-03 /pmc/articles/PMC6605748/ /pubmed/31160320 http://dx.doi.org/10.1084/jem.20190114 Text en © 2019 Laidlaw et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Research Articles
Laidlaw, Brian J.
Gray, Elizabeth E.
Zhang, Yang
Ramírez-Valle, Francisco
Cyster, Jason G.
Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin
title Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin
title_full Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin
title_fullStr Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin
title_full_unstemmed Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin
title_short Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin
title_sort sphingosine-1-phosphate receptor 2 restrains egress of γδ t cells from the skin
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605748/
https://www.ncbi.nlm.nih.gov/pubmed/31160320
http://dx.doi.org/10.1084/jem.20190114
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