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Defects in the origin licensing checkpoint stresses cells exiting G0

The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing...

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Detalles Bibliográficos
Autor principal: Blow, J. Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605787/
https://www.ncbi.nlm.nih.gov/pubmed/31266845
http://dx.doi.org/10.1083/jcb.201905181