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Defects in the origin licensing checkpoint stresses cells exiting G0
The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Rockefeller University Press
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605787/ https://www.ncbi.nlm.nih.gov/pubmed/31266845 http://dx.doi.org/10.1083/jcb.201905181 |
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author | Blow, J. Julian |
author_facet | Blow, J. Julian |
author_sort | Blow, J. Julian |
collection | PubMed |
description | The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing and consequent replicative stress. |
format | Online Article Text |
id | pubmed-6605787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-66057872020-01-01 Defects in the origin licensing checkpoint stresses cells exiting G0 Blow, J. Julian J Cell Biol Commentaries The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing and consequent replicative stress. Rockefeller University Press 2019-07-01 2019-06-11 /pmc/articles/PMC6605787/ /pubmed/31266845 http://dx.doi.org/10.1083/jcb.201905181 Text en © 2019 Blow http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Commentaries Blow, J. Julian Defects in the origin licensing checkpoint stresses cells exiting G0 |
title | Defects in the origin licensing checkpoint stresses cells exiting G0 |
title_full | Defects in the origin licensing checkpoint stresses cells exiting G0 |
title_fullStr | Defects in the origin licensing checkpoint stresses cells exiting G0 |
title_full_unstemmed | Defects in the origin licensing checkpoint stresses cells exiting G0 |
title_short | Defects in the origin licensing checkpoint stresses cells exiting G0 |
title_sort | defects in the origin licensing checkpoint stresses cells exiting g0 |
topic | Commentaries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605787/ https://www.ncbi.nlm.nih.gov/pubmed/31266845 http://dx.doi.org/10.1083/jcb.201905181 |
work_keys_str_mv | AT blowjjulian defectsintheoriginlicensingcheckpointstressescellsexitingg0 |