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Defects in the origin licensing checkpoint stresses cells exiting G0

The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing...

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Detalles Bibliográficos
Autor principal: Blow, J. Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605787/
https://www.ncbi.nlm.nih.gov/pubmed/31266845
http://dx.doi.org/10.1083/jcb.201905181
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author Blow, J. Julian
author_facet Blow, J. Julian
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description The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing and consequent replicative stress.
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spelling pubmed-66057872020-01-01 Defects in the origin licensing checkpoint stresses cells exiting G0 Blow, J. Julian J Cell Biol Commentaries The full licensing of replication origins in late G1 is normally enforced by the licensing checkpoint. In this issue, Matson et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902143) show that this checkpoint is inoperative in cells exiting from G0, resulting in incomplete origin licensing and consequent replicative stress. Rockefeller University Press 2019-07-01 2019-06-11 /pmc/articles/PMC6605787/ /pubmed/31266845 http://dx.doi.org/10.1083/jcb.201905181 Text en © 2019 Blow http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Blow, J. Julian
Defects in the origin licensing checkpoint stresses cells exiting G0
title Defects in the origin licensing checkpoint stresses cells exiting G0
title_full Defects in the origin licensing checkpoint stresses cells exiting G0
title_fullStr Defects in the origin licensing checkpoint stresses cells exiting G0
title_full_unstemmed Defects in the origin licensing checkpoint stresses cells exiting G0
title_short Defects in the origin licensing checkpoint stresses cells exiting G0
title_sort defects in the origin licensing checkpoint stresses cells exiting g0
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605787/
https://www.ncbi.nlm.nih.gov/pubmed/31266845
http://dx.doi.org/10.1083/jcb.201905181
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