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SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL
In mammals, centrioles participate in brain development, and human mutations affecting centriole duplication cause microcephaly. Here, we identify a role for the mammalian homologue of yeast SFI1, involved in the duplication of the yeast spindle pole body, as a critical regulator of centriole duplic...
Autores principales: | Kodani, Andrew, Moyer, Tyler, Chen, Allen, Holland, Andrew, Walsh, Christopher A., Reiter, Jeremy F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605807/ https://www.ncbi.nlm.nih.gov/pubmed/31197030 http://dx.doi.org/10.1083/jcb.201803041 |
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