The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P(2)

Loss of the phosphoinositide 5-phosphatase OCRL causes accumulation of PtdIns(4,5)P(2) on membranes and, ultimately, Lowe syndrome. In this issue, Mondin et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201805155) discover that a surprising partnership between PTEN and the phospholipase PLCXD...

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Detalles Bibliográficos
Autores principales: Del Signore, Steven J., Rodal, Avital A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605809/
https://www.ncbi.nlm.nih.gov/pubmed/31189610
http://dx.doi.org/10.1083/jcb.201906022
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author Del Signore, Steven J.
Rodal, Avital A.
author_facet Del Signore, Steven J.
Rodal, Avital A.
author_sort Del Signore, Steven J.
collection PubMed
description Loss of the phosphoinositide 5-phosphatase OCRL causes accumulation of PtdIns(4,5)P(2) on membranes and, ultimately, Lowe syndrome. In this issue, Mondin et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201805155) discover that a surprising partnership between PTEN and the phospholipase PLCXD can compensate for OCRL to suppress endosomal PtdIns(4,5)P(2) accumulation.
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spelling pubmed-66058092020-01-01 The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P(2) Del Signore, Steven J. Rodal, Avital A. J Cell Biol Commentaries Loss of the phosphoinositide 5-phosphatase OCRL causes accumulation of PtdIns(4,5)P(2) on membranes and, ultimately, Lowe syndrome. In this issue, Mondin et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201805155) discover that a surprising partnership between PTEN and the phospholipase PLCXD can compensate for OCRL to suppress endosomal PtdIns(4,5)P(2) accumulation. Rockefeller University Press 2019-07-01 2019-06-12 /pmc/articles/PMC6605809/ /pubmed/31189610 http://dx.doi.org/10.1083/jcb.201906022 Text en © 2019 Del Signore and Rodal http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Del Signore, Steven J.
Rodal, Avital A.
The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P(2)
title The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P(2)
title_full The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P(2)
title_fullStr The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P(2)
title_full_unstemmed The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P(2)
title_short The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P(2)
title_sort enemy of my enemy: pten and plcxd collude to fight endosomal ptdins(4,5)p(2)
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605809/
https://www.ncbi.nlm.nih.gov/pubmed/31189610
http://dx.doi.org/10.1083/jcb.201906022
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