Cargando…
The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P(2)
Loss of the phosphoinositide 5-phosphatase OCRL causes accumulation of PtdIns(4,5)P(2) on membranes and, ultimately, Lowe syndrome. In this issue, Mondin et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201805155) discover that a surprising partnership between PTEN and the phospholipase PLCXD...
Autores principales: | Del Signore, Steven J., Rodal, Avital A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605809/ https://www.ncbi.nlm.nih.gov/pubmed/31189610 http://dx.doi.org/10.1083/jcb.201906022 |
Ejemplares similares
-
PtdIns4KIIα generates endosomal PtdIns(4)P and is required for receptor sorting at early endosomes
por: Henmi, Yuji, et al.
Publicado: (2016) -
Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2)
por: Hammond, Gerald R. V., et al.
Publicado: (2009) -
PtdIns(4,5)P(2) and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance
por: Cheng, Shiya, et al.
Publicado: (2015) -
PTEN reduces endosomal PtdIns(4,5)P(2) in a phosphatase-independent manner via a PLC pathway
por: Mondin, Virginie E., et al.
Publicado: (2019) -
Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P(2) synthesis
por: de la Cruz, Lizbeth, et al.
Publicado: (2022)