PTEN reduces endosomal PtdIns(4,5)P(2) in a phosphatase-independent manner via a PLC pathway

The tumor suppressor PTEN dephosphorylates PtdIns(3,4,5)P(3) into PtdIns(4,5)P(2). Here, we make the unexpected discovery that in Drosophila melanogaster PTEN reduces PtdIns(4,5)P(2) levels on endosomes, independently of its phosphatase activity. This new PTEN function requires the enzymatic action...

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Detalles Bibliográficos
Autores principales: Mondin, Virginie E., Ben El Kadhi, Khaled, Cauvin, Clothilde, Jackson-Crawford, Anthony, Bélanger, Emilie, Decelle, Barbara, Salomon, Rémi, Lowe, Martin, Echard, Arnaud, Carréno, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605811/
https://www.ncbi.nlm.nih.gov/pubmed/31118240
http://dx.doi.org/10.1083/jcb.201805155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605811/
https://www.ncbi.nlm.nih.gov/pubmed/31118240
http://dx.doi.org/10.1083/jcb.201805155

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