NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma

Squamous cell carcinomas (SCCs) account for the majority of cancer mortalities. Although TP63 is an established lineage-survival oncogene in SCCs, therapeutic strategies have not been developed to target TP63 or it’s downstream effectors. In this study we demonstrate that TP63 directly regulates NRG...

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Detalles Bibliográficos
Autores principales: Hegde, Ganapati V, de la Cruz, Cecile, Giltnane, Jennifer M, Crocker, Lisa, Venkatanarayan, Avinashnarayan, Schaefer, Gabriele, Dunlap, Debra, Hoeck, Joerg D, Piskol, Robert, Gnad, Florian, Modrusan, Zora, de Sauvage, Frederic J, Siebel, Christian W, Jackson, Erica L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606022/
https://www.ncbi.nlm.nih.gov/pubmed/31144617
http://dx.doi.org/10.7554/eLife.46551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606022/
https://www.ncbi.nlm.nih.gov/pubmed/31144617
http://dx.doi.org/10.7554/eLife.46551

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