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Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion
Epithelial fusion underlies many vital organogenic processes during embryogenesis. Disruptions to these cause a significant number of human birth defects, including ocular coloboma. We provide robust spatial-temporal staging and unique anatomical detail of optic fissure closure (OFC) in the embryoni...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606025/ https://www.ncbi.nlm.nih.gov/pubmed/31162046 http://dx.doi.org/10.7554/eLife.43877 |