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An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells

Delivery into mammalian cells remains a significant challenge for many applications of proteins as research tools and therapeutics. We recently reported that the fusion of cargo proteins to a supernegatively charged (–30)GFP enhances encapsulation by cationic lipids and delivery into mammalian cells...

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Detalles Bibliográficos
Autores principales: Kim, Y. Bill, Zhao, Kevin T., Thompson, David B., Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606574/
https://www.ncbi.nlm.nih.gov/pubmed/31266953
http://dx.doi.org/10.1038/s41467-019-10828-3