Cargando…

Pancreatic alpha-cell mass in the early-onset and advanced stage of a mouse model of experimental autoimmune diabetes

Most studies in type 1 diabetes (T1D) have focused on the loss of the pancreatic beta-cell population. However, despite the involvement of the alpha-cell in the aetiology and complications of T1D, little is known about the regulation of the pancreatic alpha-cell mass in this disease. The need for a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bru-Tari, Eva, Cobo-Vuilleumier, Nadia, Alonso-Magdalena, Paloma, Dos Santos, Reinaldo S., Marroqui, Laura, Nadal, Angel, Gauthier, Benoit R., Quesada, Ivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606577/ https://www.ncbi.nlm.nih.gov/pubmed/31266981 http://dx.doi.org/10.1038/s41598-019-45853-1

Ejemplares similares

Pancreatic alpha-cells from female mice undergo morphofunctional changes during compensatory adaptations of the endocrine pancreas to diet-induced obesity
por: Merino, Beatriz, et al.
Publicado: (2015)

Timing of Exposure and Bisphenol-A: Implications for Diabetes Development
por: Tudurí, Eva, et al.
Publicado: (2018)

Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca(2+) entry in mouse pancreatic β-cells
por: Villar-Pazos, Sabrina, et al.
Publicado: (2017)

Involvement of the Clock Gene Rev-erb alpha in the Regulation of Glucagon Secretion in Pancreatic Alpha-Cells
por: Vieira, Elaine, et al.
Publicado: (2013)

Author Correction: Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca(2+) entry in mouse pancreatic β-cells
por: Villar-Pazos, Sabrina, et al.
Publicado: (2018)

Screening of Metabolism-Disrupting Chemicals on Pancreatic α-Cells Using In Vitro Methods
por: Dos Santos, Reinaldo Sousa, et al.
Publicado: (2022)

OR23-3 Differential Effects of Chronic Exposure to Bisphenol-A on Ion Channel Activity and Expression in Mouse Pancreatic Beta-Cells
por: Nadal, Angel, et al.
Publicado: (2019)

In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic β-Cell Model
por: Dos Santos, Reinaldo Sousa, et al.
Publicado: (2022)

BCL-XL Overexpression Protects Pancreatic β-Cells against Cytokine- and Palmitate-Induced Apoptosis
por: Perez-Serna, Atenea A., et al.
Publicado: (2023)

Prenatal Exposure to BPA and Offspring Outcomes: The Diabesogenic Behavior of BPA
por: Alonso-Magdalena, Paloma, et al.
Publicado: (2015)

SAT-715 Bisphenol-A Alters Pancreatic B-Cell Proliferation and Mass in an Estrogen Receptor Beta-Dependent Manner
por: Nadal, Angel, et al.
Publicado: (2020)

Pancreatic Alpha-Cell Dysfunction Contributes to the Disruption of Glucose Homeostasis and Compensatory Insulin Hypersecretion in Glucocorticoid-Treated Rats
por: Rafacho, Alex, et al.
Publicado: (2014)

Deucravacitinib, a tyrosine kinase 2 pseudokinase inhibitor, protects human EndoC-βH1 β-cells against proinflammatory insults
por: Dos Santos, Reinaldo S., et al.
Publicado: (2023)

Harnessing the Endogenous Plasticity of Pancreatic Islets: A Feasible Regenerative Medicine Therapy for Diabetes?
por: Lorenzo, Petra I., et al.
Publicado: (2021)

Targeting LRH-1/NR5A2 to treat type 1 diabetes mellitus
por: Cobo-Vuilleumier, Nadia, et al.
Publicado: (2018)

Roles of extracellular vesicles associated non-coding RNAs in Diabetes Mellitus
por: Gauthier, Benoit R., et al.
Publicado: (2022)

Pancreatic Insulin Content Regulation by the Estrogen Receptor ERα
por: Alonso-Magdalena, Paloma, et al.
Publicado: (2008)

Exposure to Bisphenol-A during Pregnancy Partially Mimics the Effects of a High-Fat Diet Altering Glucose Homeostasis and Gene Expression in Adult Male Mice
por: García-Arevalo, Marta, et al.
Publicado: (2014)

Inhibitory Effects of Leptin on Pancreatic α-Cell Function
por: Tudurí, Eva, et al.
Publicado: (2009)

Islet β-Cell Mass Preservation and Regeneration in Diabetes Mellitus: Four Factors with Potential Therapeutic Interest
por: Mellado-Gil, Jose Manuel, et al.
Publicado: (2012)

Corrigendum to “Islet β-Cell Mass Preservation and Regeneration in Diabetes Mellitus: Four Factors with Potential Therapeutic Interest”
por: Mellado-Gil, Jose Manuel, et al.
Publicado: (2019)

Bisphenol A Regulates Sodium Ramp Currents in Mouse Dorsal Root Ganglion Neurons and Increases Nociception
por: Soriano, Sergi, et al.
Publicado: (2019)

Bisphenol A Exposure during Pregnancy Disrupts Glucose Homeostasis in Mothers and Adult Male Offspring
por: Alonso-Magdalena, Paloma, et al.
Publicado: (2010)

The Estrogenic Effect of Bisphenol A Disrupts Pancreatic β-Cell Function In Vivo and Induces Insulin Resistance
por: Alonso-Magdalena, Paloma, et al.
Publicado: (2006)

Molecular Modelling of Islet β-Cell Adaptation to Inflammation in Pregnancy and Gestational Diabetes Mellitus
por: Lorenzo, Petra I., et al.
Publicado: (2019)

Cortistatin hyperpolarizes pancreatic beta cell membrane and reduces glucose-stimulated insulin secretion
por: Rafacho, Alex, et al.
Publicado: (2015)

PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus
por: Mellado-Gil, José Manuel, et al.
Publicado: (2016)

The Diabetes-Linked Transcription Factor PAX4: From Gene to Functional Consequences
por: Lorenzo, Petra I., et al.
Publicado: (2017)

The PTGS2/COX2-PGE(2) signaling cascade in inflammation: Pro or anti? A case study with type 1 diabetes mellitus
por: Martín-Vázquez, Eugenia, et al.
Publicado: (2023)

Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine tumors
por: Lorenzo, Petra I., et al.
Publicado: (2011)

Exploring the Effects of Metabolism-Disrupting Chemicals on Pancreatic α-Cell Viability, Gene Expression and Function: A Screening Testing Approach
por: Al-Abdulla, Ruba, et al.
Publicado: (2023)

Umbilical cord mesenchymal stromal cells transplantation delays the onset of hyperglycemia in the RIP-B7.1 mouse model of experimental autoimmune diabetes through multiple immunosuppressive and anti-inflammatory responses
por: Lachaud, C. C., et al.
Publicado: (2023)

Insulinotropic Effect of the Non-Steroidal Compound STX in Pancreatic β-Cells
por: Ropero, Ana B., et al.
Publicado: (2012)

Rapid Insulinotropic Action of Low Doses of Bisphenol-A on Mouse and Human Islets of Langerhans: Role of Estrogen Receptor β
por: Soriano, Sergi, et al.
Publicado: (2012)

Correction: Insulinotropic Effect of the Non-Steroidal Compound STX in Pancreatic β-Cells
por: Ropero, Ana B., et al.
Publicado: (2012)

Antidiabetic Actions of an Estrogen Receptor β Selective Agonist
por: Alonso-Magdalena, Paloma, et al.
Publicado: (2013)

Low Doses of Bisphenol A and Diethylstilbestrol Impair Ca(2+) Signals in Pancreatic α-Cells through a Nonclassical Membrane Estrogen Receptor within Intact Islets of Langerhans
por: Alonso-Magdalena, Paloma, et al.
Publicado: (2005)

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes
por: Marroqui, Laura, et al.
Publicado: (2015)

PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet
por: Lorenzo, Petra I., et al.
Publicado: (2015)

Short-Term Treatment with Bisphenol-A Leads to Metabolic Abnormalities in Adult Male Mice
por: Batista, Thiago M., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_s3bd8if8vvaf7gume40ev3eonq