Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology

Cohesin and CTCF are master regulators of genome topology. How these ubiquitous proteins contribute to cell-type specific genome structure is poorly understood. Here, we explore quantitative aspects of topologically associated domains (TAD) between pluripotent embryonic stem cells (ESC) and lineage-...

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Detalles Bibliográficos
Autores principales: Barrington, Christopher, Georgopoulou, Dimitra, Pezic, Dubravka, Varsally, Wazeer, Herrero, Javier, Hadjur, Suzana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606583/
https://www.ncbi.nlm.nih.gov/pubmed/31266948
http://dx.doi.org/10.1038/s41467-019-10725-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606583/
https://www.ncbi.nlm.nih.gov/pubmed/31266948
http://dx.doi.org/10.1038/s41467-019-10725-9

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