Nasal delivery of donepezil HCl-loaded hydrogels for the treatment of Alzheimer’s disease

This study aims to prepare, characterize and evaluate the pharmacokinetics of liposomal donepezil HCl (LDH) dispersed into thiolated chitosan hydrogel (TCH) in rabbits. Various hydrogels including TCH were prepared, and after characterization, TCH was selected for subsequent evaluations, due to the...

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Detalles Bibliográficos
Autores principales: Al Harthi, Sitah, Alavi, Seyed Ebrahim, Radwan, Mahasen Ali, El Khatib, Mona Mohamed, AlSarra, Ibrahim Abdullah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606601/
https://www.ncbi.nlm.nih.gov/pubmed/31266990
http://dx.doi.org/10.1038/s41598-019-46032-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606601/
https://www.ncbi.nlm.nih.gov/pubmed/31266990
http://dx.doi.org/10.1038/s41598-019-46032-y

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