Targeting of replicating CD133 and OCT4/SOX2 expressing glioma stem cells selects a cell population that reinitiates tumors upon release of therapeutic pressure

The existence of radio- and chemotherapy-surviving cancer stem cells is currently believed to explain the inefficacy of anti-glioblastoma (GBM) therapies. The aim of this study was to determine if a therapeutic strategy specifically targeting GBM stem cells (GSC) would completely eradicate a GBM tum...

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Detalles Bibliográficos
Autores principales: Guerra-Rebollo, Marta, Garrido, Cristina, Sánchez-Cid, Lourdes, Soler-Botija, Carolina, Meca-Cortés, Oscar, Rubio, Nuria, Blanco, Jerónimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606606/
https://www.ncbi.nlm.nih.gov/pubmed/31267022
http://dx.doi.org/10.1038/s41598-019-46014-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606606/
https://www.ncbi.nlm.nih.gov/pubmed/31267022
http://dx.doi.org/10.1038/s41598-019-46014-0

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