Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis

Stochastic formation of Mycobacterium tuberculosis (Mtb) persisters achieves a high level of antibiotic-tolerance and serves as a source of multidrug-resistant (MDR) mutations. As conventional treatment is not effective against infections by persisters and MDR-Mtb, novel therapeutics are needed. Sev...

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Detalles Bibliográficos
Autores principales: Lee, Jae Jin, Lee, Sun-Kyung, Song, Naomi, Nathan, Temitope O., Swarts, Benjamin M., Eum, Seok-Yong, Ehrt, Sabine, Cho, Sang-Nae, Eoh, Hyungjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606615/
https://www.ncbi.nlm.nih.gov/pubmed/31266959
http://dx.doi.org/10.1038/s41467-019-10975-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606615/
https://www.ncbi.nlm.nih.gov/pubmed/31266959
http://dx.doi.org/10.1038/s41467-019-10975-7

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