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Single-cell RNA-seq variant analysis for exploration of genetic heterogeneity in cancer
Inter- and intra-tumour heterogeneity is caused by genetic and non-genetic factors, leading to severe clinical implications. High-throughput sequencing technologies provide unprecedented tools to analyse DNA and RNA in single cells and explore both genetic heterogeneity and phenotypic variation betw...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606766/ https://www.ncbi.nlm.nih.gov/pubmed/31267007 http://dx.doi.org/10.1038/s41598-019-45934-1 |