Enhancement of Adeno-Associated Virus-Mediated Gene Therapy Using Hydroxychloroquine in Murine and Human Tissues

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The therapeutic effects of gene therapy using adeno-associated virus (AAV) vectors are dependent on the efficacy of viral transduction. Currently, we have reached the safe limits of AAV vector dose, beyond which damaging inflammatory responses are seen. To improve the efficacy of AAV transduction, w...

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Detalles Bibliográficos
Autores principales: Chandler, Laurel C., Barnard, Alun R., Caddy, Sarah L., Patrício, Maria I., McClements, Michelle E., Fu, Howell, Rada, Cristina, MacLaren, Robert E., Xue, Kanmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606965/
https://www.ncbi.nlm.nih.gov/pubmed/31309129
http://dx.doi.org/10.1016/j.omtm.2019.05.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606965/
https://www.ncbi.nlm.nih.gov/pubmed/31309129
http://dx.doi.org/10.1016/j.omtm.2019.05.012

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