Drug‐induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann–Pick type C cells and mice

Most cells acquire cholesterol by endocytosis of circulating low‐density lipoproteins (LDLs). After cholesteryl ester de‐esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms. Our previous work suggested that the unconventional phospholipid...

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Detalles Bibliográficos
Autores principales: Moreau, Dimitri, Vacca, Fabrizio, Vossio, Stefania, Scott, Cameron, Colaco, Alexandria, Paz Montoya, Jonathan, Ferguson, Charles, Damme, Markus, Moniatte, Marc, Parton, Robert G, Platt, Frances M, Gruenberg, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607015/
https://www.ncbi.nlm.nih.gov/pubmed/31267706
http://dx.doi.org/10.15252/embr.201847055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607015/
https://www.ncbi.nlm.nih.gov/pubmed/31267706
http://dx.doi.org/10.15252/embr.201847055

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