CXCR4 antagonism in combination with IDO1 inhibition weakens immune suppression and inhibits tumor growth in mouse breast cancer bone metastases

PURPOSE: To investigate whether inhibition of the CXCL12/CXCR4 axis or IDO1 could produce antitumor effects in a metastasized breast cancer immunocompetent animal model. METHODS: Breast cancer metastasis models were established in mice. CXCR4 inhibitor and IDO1 inhibitor were used to evaluate the an...

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Detalles Bibliográficos
Autores principales: Zhang, Jian, Pang, Yanxia, Xie, Tao, Zhu, Liulong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607200/
https://www.ncbi.nlm.nih.gov/pubmed/31388305
http://dx.doi.org/10.2147/OTT.S200643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607200/
https://www.ncbi.nlm.nih.gov/pubmed/31388305
http://dx.doi.org/10.2147/OTT.S200643

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