T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response

BACKGROUND: Treatments for autoimmune diseases aim to dampen autoreactivity while preserving normal immune function. In CD4(+) T cells, the transcription factor Oct1/Pou2f1 is a dispensable transcription factor for T cell development and response to primary infection, but promotes expression of targ...

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Detalles Bibliográficos
Autores principales: Kim, Heejoo, Dickey, Laura, Stone, Colleen, Jafek, Jillian L., Lane, Thomas E., Tantin, Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607600/
https://www.ncbi.nlm.nih.gov/pubmed/31266507
http://dx.doi.org/10.1186/s12974-019-1523-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607600/
https://www.ncbi.nlm.nih.gov/pubmed/31266507
http://dx.doi.org/10.1186/s12974-019-1523-3

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