Plasticity enhancement in pharmaceutical drugs by water of crystallization: unusual slip planes

Khandavilli et al. [(2019), IUCrJ, 6, 630–634] show the superior plasticity in hydrates of the pharmaceutical drugs, pregabalin and gabapetin, compared with their anhydrous forms. The water in the structure is believed to act as a lubricating agent in the packing of hydrates, thus facilitating slipp...

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Detalles Bibliográficos
Autor principal: Reddy, C. Malla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Scientific Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608643/
https://www.ncbi.nlm.nih.gov/pubmed/31316794
http://dx.doi.org/10.1107/S205225251900890X
Descripción
Sumario:Khandavilli et al. [(2019), IUCrJ, 6, 630–634] show the superior plasticity in hydrates of the pharmaceutical drugs, pregabalin and gabapetin, compared with their anhydrous forms. The water in the structure is believed to act as a lubricating agent in the packing of hydrates, thus facilitating slippage of molecules in the plastic bending of the crystals under external mechanical stress.

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