Plasticity enhancement in pharmaceutical drugs by water of crystallization: unusual slip planes

Khandavilli et al. [(2019), IUCrJ, 6, 630–634] show the superior plasticity in hydrates of the pharmaceutical drugs, pregabalin and gabapetin, compared with their anhydrous forms. The water in the structure is believed to act as a lubricating agent in the packing of hydrates, thus facilitating slipp...

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Detalles Bibliográficos
Autor principal: Reddy, C. Malla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Scientific Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608643/
https://www.ncbi.nlm.nih.gov/pubmed/31316794
http://dx.doi.org/10.1107/S205225251900890X
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author Reddy, C. Malla
author_facet Reddy, C. Malla
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description Khandavilli et al. [(2019), IUCrJ, 6, 630–634] show the superior plasticity in hydrates of the pharmaceutical drugs, pregabalin and gabapetin, compared with their anhydrous forms. The water in the structure is believed to act as a lubricating agent in the packing of hydrates, thus facilitating slippage of molecules in the plastic bending of the crystals under external mechanical stress.
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spelling pubmed-66086432019-07-17 Plasticity enhancement in pharmaceutical drugs by water of crystallization: unusual slip planes Reddy, C. Malla IUCrJ Scientific Commentaries Khandavilli et al. [(2019), IUCrJ, 6, 630–634] show the superior plasticity in hydrates of the pharmaceutical drugs, pregabalin and gabapetin, compared with their anhydrous forms. The water in the structure is believed to act as a lubricating agent in the packing of hydrates, thus facilitating slippage of molecules in the plastic bending of the crystals under external mechanical stress. International Union of Crystallography 2019-06-28 /pmc/articles/PMC6608643/ /pubmed/31316794 http://dx.doi.org/10.1107/S205225251900890X Text en © C. Malla Reddy 2019 http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/4.0/
spellingShingle Scientific Commentaries
Reddy, C. Malla
Plasticity enhancement in pharmaceutical drugs by water of crystallization: unusual slip planes
title Plasticity enhancement in pharmaceutical drugs by water of crystallization: unusual slip planes
title_full Plasticity enhancement in pharmaceutical drugs by water of crystallization: unusual slip planes
title_fullStr Plasticity enhancement in pharmaceutical drugs by water of crystallization: unusual slip planes
title_full_unstemmed Plasticity enhancement in pharmaceutical drugs by water of crystallization: unusual slip planes
title_short Plasticity enhancement in pharmaceutical drugs by water of crystallization: unusual slip planes
title_sort plasticity enhancement in pharmaceutical drugs by water of crystallization: unusual slip planes
topic Scientific Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608643/
https://www.ncbi.nlm.nih.gov/pubmed/31316794
http://dx.doi.org/10.1107/S205225251900890X
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