ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumor progression

The c-Myc oncogene (MYC) drives malignant progression, but also induces robust anabolic and proliferative programs leading to intrinsic stress. The mechanisms enabling adaptation to MYC-induced stress are not fully understood. We have uncovered an essential role for the transcription factor ATF4 in...

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Detalles Bibliográficos
Autores principales: Tameire, Feven, Verginadis, Ioannis I., Leli, Nektaria Maria, Polte, Christine, Conn, Crystal S., Ojha, Rani, Salas, Carlo, Chinga, Frank, Monroy, Alexandra. M., Fu, Weixuan, Wang, Paul, Kossenkov, Andrew, Ye, Jiangbin, Amaravadi, Ravi K., Ignatova, Zoya, Fuchs, Serge Y., Diehl, J. Alan, Ruggero, Davide, Koumenis, Constantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608727/
https://www.ncbi.nlm.nih.gov/pubmed/31263264
http://dx.doi.org/10.1038/s41556-019-0347-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608727/
https://www.ncbi.nlm.nih.gov/pubmed/31263264
http://dx.doi.org/10.1038/s41556-019-0347-9

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