CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Using biochemical characterization of fusion proteins associated with endometrial stromal sarcoma, we identified JAZF1 as a new subunit of the NuA4 acetyltransferase complex and CXORF67 as a subunit of the Polycomb Repressive Complex 2 (PRC2). Since CXORF67’s interaction with PRC2 leads to decreased...

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Detalles Bibliográficos
Autores principales: Piunti, Andrea, Smith, Edwin R., Morgan, Marc A. J., Ugarenko, Michal, Khaltyan, Natalia, Helmin, Kathryn A., Ryan, Caila A., Murray, David C., Rickels, Ryan A., Yilmaz, Bahar D., Rendleman, Emily J., Savas, Jeffrey N., Singer, Benjamin D., Bulun, Serdar E., Shilatifard, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609211/
https://www.ncbi.nlm.nih.gov/pubmed/31281901
http://dx.doi.org/10.1126/sciadv.aax2887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609211/
https://www.ncbi.nlm.nih.gov/pubmed/31281901
http://dx.doi.org/10.1126/sciadv.aax2887

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