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Potency and plasma protein binding of drugs in vitro—a potentially misleading pair for predicting in vivo efficacious concentrations in humans
In drug discovery or preclinical stages of development, potency parameters such as IC(50), K(i), or K(d) in vitro have been routinely used to predict the parameters of efficacious exposure (AUC, C(min), etc.) in humans. However, to our knowledge, the fundamental assumption that the potency in vitro...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Korean Physiological Society and The Korean Society of Pharmacology
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609267/ https://www.ncbi.nlm.nih.gov/pubmed/31297007 http://dx.doi.org/10.4196/kjpp.2019.23.4.231 |