scDam&T‐seq combines DNA adenine methyltransferase-based labeling of protein-DNA contact sites with transcriptome sequencing to analyze regulatory programs in single cells

Protein-DNA interactions are critical to the regulation of gene expression, but it remains challenging to define how cell-to-cell heterogeneity in protein-DNA binding influences gene expression variability. Here we report a method for the simultaneous quantification of protein-DNA contacts by combin...

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Detalles Bibliográficos
Autores principales: Rooijers, Koos, Markodimitraki, Corina M., Rang, Franka J., de Vries, Sandra S., Chialastri, Alex, de Luca, Kim L., Mooijman, Dylan, Dey, Siddharth S., Kind, Jop
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609448/
https://www.ncbi.nlm.nih.gov/pubmed/31209373
http://dx.doi.org/10.1038/s41587-019-0150-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609448/
https://www.ncbi.nlm.nih.gov/pubmed/31209373
http://dx.doi.org/10.1038/s41587-019-0150-y

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