The peptide hormone glucagon forms amyloid fibrils with two coexisting β-strand conformations

Glucagon and insulin maintain blood glucose homeostasis and are used to treat hypoglycemia and hyperglycemia in diabetic patients, respectively. Whereas insulin is stable for weeks in its solution formulation, glucagon fibrillizes rapidly at the acidic pH required for solubility, and is therefore fo...

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Detalles Bibliográficos
Autores principales: Gelenter, Martin D., Smith, Katelyn J., Liao, Shu-Yu, Mandala, Venkata S., Dregni, Aurelio J., Lamm, Matthew S., Tian, Yu, Xu, Wei, Pochan, Darrin J., Tucker, Thomas J., Su, Yongchao, Hong, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609468/
https://www.ncbi.nlm.nih.gov/pubmed/31235909
http://dx.doi.org/10.1038/s41594-019-0238-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609468/
https://www.ncbi.nlm.nih.gov/pubmed/31235909
http://dx.doi.org/10.1038/s41594-019-0238-6

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