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The peptide hormone glucagon forms amyloid fibrils with two coexisting β-strand conformations
Glucagon and insulin maintain blood glucose homeostasis and are used to treat hypoglycemia and hyperglycemia in diabetic patients, respectively. Whereas insulin is stable for weeks in its solution formulation, glucagon fibrillizes rapidly at the acidic pH required for solubility, and is therefore fo...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609468/ https://www.ncbi.nlm.nih.gov/pubmed/31235909 http://dx.doi.org/10.1038/s41594-019-0238-6 |