Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis

Clonal hematopoiesis (CH) is a common aging-associated condition with increased risk of hematologic malignancy. Knowledge of the mechanisms driving evolution from CH to overt malignancy has been hampered by a lack of in vivo models that orthogonally activate mutant alleles. Here, we develop independ...

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Detalles Bibliográficos
Autores principales: Loberg, Matthew A., Bell, Rebecca K., Goodwin, Leslie O., Eudy, Elizabeth, Miles, Linde A., SanMiguel, Jennifer M., Young, Kira, Bergstrom, David E., Levine, Ross L., Schneider, Rebekka K., Trowbridge, Jennifer J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609470/
https://www.ncbi.nlm.nih.gov/pubmed/30692594
http://dx.doi.org/10.1038/s41375-018-0368-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609470/
https://www.ncbi.nlm.nih.gov/pubmed/30692594
http://dx.doi.org/10.1038/s41375-018-0368-6

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