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A photoswitchable GABA receptor channel blocker

BACKGROUND AND PURPOSE: Anion‐selective Cys‐loop receptors (GABA and glycine receptors) provide the main inhibitory drive in the CNS. Both types of receptor operate via chloride‐selective ion channels, though with different kinetics, pharmacological profiles, and localization. Disequilibrium in thei...

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Detalles Bibliográficos
Autores principales: Maleeva, Galyna, Wutz, Daniel, Rustler, Karin, Nin‐Hill, Alba, Rovira, Carme, Petukhova, Elena, Bautista‐Barrufet, Antoni, Gomila‐Juaneda, Alexandre, Scholze, Petra, Peiretti, Franck, Alfonso‐Prieto, Mercedes, König, Burkhard, Gorostiza, Pau, Bregestovski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609548/
https://www.ncbi.nlm.nih.gov/pubmed/30981211
http://dx.doi.org/10.1111/bph.14689