Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells

Mitochondrial dysfunction plays a primary role in neurodevelopmental anomalies and neurodegeneration of Down syndrome (DS) subjects. For this reason, targeting mitochondrial key genes, such as PGC-1α/PPARGC1A, is emerging as a good therapeutic approach to attenuate cognitive disability in DS. After...

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Detalles Bibliográficos
Autores principales: Mollo, Nunzia, Nitti, Maria, Zerillo, Lucrezia, Faicchia, Deriggio, Micillo, Teresa, Accarino, Rossella, Secondo, Agnese, Petrozziello, Tiziana, Calì, Gaetano, Cicatiello, Rita, Bonfiglio, Ferdinando, Sarnataro, Viviana, Genesio, Rita, Izzo, Antonella, Pinton, Paolo, Matarese, Giuseppe, Paladino, Simona, Conti, Anna, Nitsch, Lucio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609571/
https://www.ncbi.nlm.nih.gov/pubmed/31316549
http://dx.doi.org/10.3389/fgene.2019.00606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609571/
https://www.ncbi.nlm.nih.gov/pubmed/31316549
http://dx.doi.org/10.3389/fgene.2019.00606

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