Rescue of tight junctional localization of a claudin-16 mutant D97S by antimalarial medicine primaquine in Madin-Darby canine kidney cells

Magnesium ion (Mg(2+)) is paracellularly reabsorbed through claudin-16 (CLDN16) in the thick ascending limb (TAL) of Henle’s loop in the kidney. Genetic disorders of CLDN16 cause mislocalization of CLDN16, resulting in hypomagnesemia. There is no effective treatment for hypomagnesemia except for mag...

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Detalles Bibliográficos
Autores principales: Marunaka, Kana, Fujii, Naoko, Kimura, Toru, Furuta, Takumi, Hasegawa, Hajime, Matsunaga, Toshiyuki, Endo, Satoshi, Ikari, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609605/
https://www.ncbi.nlm.nih.gov/pubmed/31273276
http://dx.doi.org/10.1038/s41598-019-46250-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609605/
https://www.ncbi.nlm.nih.gov/pubmed/31273276
http://dx.doi.org/10.1038/s41598-019-46250-4

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