Engineering a humanized telomerase reverse transcriptase gene in mouse embryonic stem cells

Telomerase is expressed in adult mouse, but not in most human, tissues and mouse telomeres are much longer than those in humans. This interspecies difference of telomere homeostasis poses a challenge in modeling human diseases using laboratory mice. Using chromatinized bacterial artificial chromosom...

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Detalles Bibliográficos
Autores principales: Cheng, De, Zhao, Yuanjun, Zhang, Fan, Zhang, Jinglong, Wang, Shuwen, Zhu, Jiyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609615/
https://www.ncbi.nlm.nih.gov/pubmed/31273310
http://dx.doi.org/10.1038/s41598-019-46160-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609615/
https://www.ncbi.nlm.nih.gov/pubmed/31273310
http://dx.doi.org/10.1038/s41598-019-46160-5

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