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Engineering a humanized telomerase reverse transcriptase gene in mouse embryonic stem cells
Telomerase is expressed in adult mouse, but not in most human, tissues and mouse telomeres are much longer than those in humans. This interspecies difference of telomere homeostasis poses a challenge in modeling human diseases using laboratory mice. Using chromatinized bacterial artificial chromosom...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609615/ https://www.ncbi.nlm.nih.gov/pubmed/31273310 http://dx.doi.org/10.1038/s41598-019-46160-5 |