Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis

RNAi-based bone anabolic gene therapy has demonstrated initial success, but many practical challenges are still unmet. Here, we demonstrate that a recombinant adeno-associated virus 9 (rAAV9) is highly effective for transducing osteoblast lineage cells in the bone. The adaptor protein Schnurri-3 (SH...

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Detalles Bibliográficos
Autores principales: Yang, Yeon-Suk, Xie, Jun, Wang, Dan, Kim, Jung-Min, Tai, Phillip W. L., Gravallese, Ellen, Gao, Guangping, Shim, Jae-Hyuck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609711/
https://www.ncbi.nlm.nih.gov/pubmed/31273195
http://dx.doi.org/10.1038/s41467-019-10809-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609711/
https://www.ncbi.nlm.nih.gov/pubmed/31273195
http://dx.doi.org/10.1038/s41467-019-10809-6

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