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Inhibiting TRF1 upstream signaling pathways to target telomeres in cancer cells
In the context of tumorigenesis, telomere shortening is associated with apparent antagonistic outcomes: On one side, it favors cancer initiation through mechanisms involving genome instability, while on the other side, it prevents cancer progression, due to the activation of the DNA damage response...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609909/ https://www.ncbi.nlm.nih.gov/pubmed/31273935 http://dx.doi.org/10.15252/emmm.201910845 |