The Natural Compound Climacostol as a Prodrug Strategy Based on pH Activation for Efficient Delivery of Cytotoxic Small Agents

We synthesized and characterized MOMO as a new small molecule analog of the cytotoxic natural product climacostol efficiently activated in mild extracellular acidosis. The synthesis of MOMO had a key step in the Wittig olefination for the construction of the carbon-carbon double bond in the alkenyl...

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Detalles Bibliográficos
Autores principales: Catalani, Elisabetta, Buonanno, Federico, Lupidi, Gabriele, Bongiorni, Silvia, Belardi, Riccardo, Zecchini, Silvia, Giovarelli, Matteo, Coazzoli, Marco, De Palma, Clara, Perrotta, Cristiana, Clementi, Emilio, Prantera, Giorgio, Marcantoni, Enrico, Ortenzi, Claudio, Fausto, Anna Maria, Picchietti, Simona, Cervia, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609918/
https://www.ncbi.nlm.nih.gov/pubmed/31316972
http://dx.doi.org/10.3389/fchem.2019.00463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609918/
https://www.ncbi.nlm.nih.gov/pubmed/31316972
http://dx.doi.org/10.3389/fchem.2019.00463

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