Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3α signaling pathway in C2C12 myotubes and mice

Skeletal muscle wasting is a feature of cancer cachexia that increases patient morbidity and mortality. Matrine, the main bioactive component of Sophora flavescens, has been approved for the prevention and therapy of cancer cachexia in China. However, to the best of our knowledge, its mechanism in i...

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Detalles Bibliográficos
Autores principales: Chen, Li, Chen, Linlin, Wan, Lili, Huo, Yan, Huang, Jinlu, Li, Jie, Lu, Jin, Xin, Bo, Yang, Quanjun, Guo, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610044/
https://www.ncbi.nlm.nih.gov/pubmed/31233199
http://dx.doi.org/10.3892/or.2019.7205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610044/
https://www.ncbi.nlm.nih.gov/pubmed/31233199
http://dx.doi.org/10.3892/or.2019.7205

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