CRISPR knockout screen implicates three genes in lysosome function

Defective biosynthesis of the phospholipid PI(3,5)P(2) underlies neurological disorders characterized by cytoplasmic accumulation of large lysosome-derived vacuoles. To identify novel genetic causes of lysosomal vacuolization, we developed an assay for enlargement of the lysosome compartment that is...

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Detalles Bibliográficos
Autores principales: Lenk, Guy M., Park, Young N., Lemons, Rosemary, Flynn, Emma, Plank, Margaret, Frei, Christen M., Davis, Michael J., Gregorka, Brian, Swanson, Joel A., Meisler, Miriam H., Kitzman, Jacob O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610096/
https://www.ncbi.nlm.nih.gov/pubmed/31270356
http://dx.doi.org/10.1038/s41598-019-45939-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610096/
https://www.ncbi.nlm.nih.gov/pubmed/31270356
http://dx.doi.org/10.1038/s41598-019-45939-w

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