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CRISPR knockout screen implicates three genes in lysosome function
Defective biosynthesis of the phospholipid PI(3,5)P(2) underlies neurological disorders characterized by cytoplasmic accumulation of large lysosome-derived vacuoles. To identify novel genetic causes of lysosomal vacuolization, we developed an assay for enlargement of the lysosome compartment that is...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610096/ https://www.ncbi.nlm.nih.gov/pubmed/31270356 http://dx.doi.org/10.1038/s41598-019-45939-w |