Macrophages promote a profibrotic phenotype in orbital fibroblasts through increased hyaluronic acid production and cell contractility

Graves’ orbitopathy (GO) is an autoimmune inflammatory disease affecting the orbit. Orbital fibroblasts are a key component in GO pathogenesis, which includes inflammation, adipogenesis, hyaluronic acid (HA) secretion, and fibrosis. Macrophages are thought to participate in the immunological stage o...

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Detalles Bibliográficos
Autores principales: Yang, I-Hui, Rose, Geoffrey E., Ezra, Daniel G., Bailly, Maryse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610127/
https://www.ncbi.nlm.nih.gov/pubmed/31270379
http://dx.doi.org/10.1038/s41598-019-46075-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610127/
https://www.ncbi.nlm.nih.gov/pubmed/31270379
http://dx.doi.org/10.1038/s41598-019-46075-1

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