Dysfunctional MDR-1 disrupts mitochondrial homeostasis in the oocyte and ovary

Multidrug resistance transporters (MDRs) are best known for their pathological role in neoplastic evasion of chemotherapeutics and antibiotics. Here we show that MDR-1 is present in the oocyte mitochondrial membrane, and it protects the female gamete from oxidative stress. Female mdr1a mutant mice h...

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Detalles Bibliográficos
Autores principales: Clark, Haley, Knapik, Laura O., Zhang, Zijing, Wu, Xiaotian, Naik, Mandar T., Oulhen, Nathalie, Wessel, Gary M., Brayboy, Lynae M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610133/
https://www.ncbi.nlm.nih.gov/pubmed/31270386
http://dx.doi.org/10.1038/s41598-019-46025-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610133/
https://www.ncbi.nlm.nih.gov/pubmed/31270386
http://dx.doi.org/10.1038/s41598-019-46025-x

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