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Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse

Extracellular-signal-regulated kinases (ERK) 1 and 2 regulate many aspects of the hypothalamic-pituitary-gonadal axis. We sought to understand the role of ERK1/2 signaling in cells expressing a Cre allele regulated by the endogenous GnRHR promoter (GRIC-ERKdko). Adult female GRIC-ERKdko mice were hy...

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Detalles Bibliográficos
Autores principales: Brown, Jessica L., Sones, Jennifer L., Angulo, Cynthia N., Abbott, Keelin, Miller, Andrew D., Boehm, Ulrich, Roberson, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610138/
https://www.ncbi.nlm.nih.gov/pubmed/31270345
http://dx.doi.org/10.1038/s41598-019-45997-0