Huntington’s Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support

In Huntington’s disease (HD), while the ubiquitously expressed mutant Huntingtin (mtHTT) protein primarily compromises striatal and cortical neurons, glia also undergo disease-contributing alterations. Existing HD models using human induced pluripotent stem cells (iPSCs) have not extensively charact...

Descripción completa

Detalles Bibliográficos
Autores principales: Garcia, Veronica J., Rushton, David J., Tom, Colton M., Allen, Nicholas D., Kemp, Paul J., Svendsen, Clive N., Mattis, Virginia B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610155/
https://www.ncbi.nlm.nih.gov/pubmed/31316341
http://dx.doi.org/10.3389/fnins.2019.00669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610155/
https://www.ncbi.nlm.nih.gov/pubmed/31316341
http://dx.doi.org/10.3389/fnins.2019.00669

Ejemplares similares