Cargando…

Huntington’s Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support

In Huntington’s disease (HD), while the ubiquitously expressed mutant Huntingtin (mtHTT) protein primarily compromises striatal and cortical neurons, glia also undergo disease-contributing alterations. Existing HD models using human induced pluripotent stem cells (iPSCs) have not extensively charact...

Descripción completa

Detalles Bibliográficos
Autores principales:	Garcia, Veronica J., Rushton, David J., Tom, Colton M., Allen, Nicholas D., Kemp, Paul J., Svendsen, Clive N., Mattis, Virginia B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610155/ https://www.ncbi.nlm.nih.gov/pubmed/31316341 http://dx.doi.org/10.3389/fnins.2019.00669

Ejemplares similares

Stimulation of GABA-Induced Ca(2+) Influx Enhances Maturation of Human Induced Pluripotent Stem Cell-Derived Neurons
por: Rushton, David J., et al.
Publicado: (2013)

Optimization of trans-Splicing for Huntington's Disease RNA Therapy
por: Rindt, Hansjörg, et al.
Publicado: (2017)

Characterization of Neurodevelopmental Abnormalities in iPSC-Derived Striatal Cultures from Patients with Huntington’s Disease
por: Mathkar, Pranav P., et al.
Publicado: (2019)

The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons
por: Machiela, Emily, et al.
Publicado: (2020)

The Role of Microglia and Astrocytes in Huntington’s Disease
por: Palpagama, Thulani H., et al.
Publicado: (2019)

Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes
por: Contino, Sabrina, et al.
Publicado: (2021)

Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease
por: Wu, Zheng, et al.
Publicado: (2020)

Amyloid-β Impairs Vesicular Secretion in Neuronal and Astrocyte Peptidergic Transmission
por: Plá, Virginia, et al.
Publicado: (2017)

Cerebral organoids exhibit mature neurons and astrocytes and recapitulate electrophysiological activity of the human brain
por: Yakoub, Abraam M.
Publicado: (2019)

Abnormal Electrophysiological Motor Responses in Huntington’s Disease: Evidence of Premanifest Compensation
por: Turner, Lauren M., et al.
Publicado: (2015)

GSK-3β-induced Tau pathology drives hippocampal neuronal cell death in Huntington's disease: involvement of astrocyte–neuron interactions
por: L'Episcopo, F, et al.
Publicado: (2016)

Genetic mouse models of Huntington’s disease: focus on electrophysiological mechanisms
por: Cepeda, Carlos, et al.
Publicado: (2010)

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice
por: Tong, Xiaoping, et al.
Publicado: (2014)

Data Acquisition and Display for Electrophysiology: PC Oscilloscopes
por: George, Stephen
Publicado: (2006)

Neuroinflammation in Huntington’s Disease: A Starring Role for Astrocyte and Microglia
por: Saba, Julieta, et al.
Publicado: (2022)

ALS associated mutant SOD1 impairs the motor neurons and astrocytes and wild type astrocyte secreted-factors reverse the impaired motor neurons
por: Thangavelu, Soundara Rajan, et al.
Publicado: (2011)

Striatal parvalbuminergic neurons are lost in Huntington's disease: implications for dystonia
por: Reiner, Anton, et al.
Publicado: (2013)

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects
por: Faideau, Mathilde, et al.
Publicado: (2010)

Electrophysiological behavior of neonatal astrocytes in hippocampal stratum radiatum
por: Zhong, Shiying, et al.
Publicado: (2016)

Extracellular Electrophysiological Measurements of Cooperative Signals in Astrocytes Populations
por: Mestre, Ana L. G., et al.
Publicado: (2017)

Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's disease
por: Pircs, Karolina, et al.
Publicado: (2021)

Electrophysiological In Vitro Study of Long‐Range Signal Transmission by Astrocytic Networks
por: Hastings, Nataly, et al.
Publicado: (2023)

Reactive astrocytes in ALS display diminished intron retention
por: Ziff, Oliver J, et al.
Publicado: (2021)

Electrophysiology of the neuron : an interactive tutorial
por: Huguenard, John

Single-nucleus RNA-seq identifies Huntington disease astrocyte states
por: Al-Dalahmah, Osama, et al.
Publicado: (2020)

Diminished LC3-Associated Phagocytosis by Huntington’s Disease Striatal Astrocytes
por: Wakida, Nicole M., et al.
Publicado: (2022)

Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington’s disease
por: Villanueva, Carlos Benitez, et al.
Publicado: (2023)

Striatal morphology correlates with frontostriatal electrophysiological motor processing in Huntington's disease: an IMAGE‐HD study
por: Turner, Lauren M., et al.
Publicado: (2016)

Inducible Expression of GDNF in Transplanted iPSC-Derived Neural Progenitor Cells
por: Akhtar, Aslam Abbasi, et al.
Publicado: (2018)

The nestin-expressing and non-expressing neurons in rat basal forebrain display different electrophysiological properties and project to hippocampus
por: Zhu, Jianhua, et al.
Publicado: (2011)

Astrocytes as metabolic suppliers to support neuronal activity and brain functions
por: Roumes, Hélène, et al.
Publicado: (2023)

Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease
por: Smith-Dijak, Amy I., et al.
Publicado: (2019)

Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes
por: Vadodaria, Krishna C., et al.
Publicado: (2021)

Amelioration of Huntington’s disease phenotype in astrocytes derived from iPSC-derived neural progenitor cells of Huntington’s disease monkeys
por: Cho, In Ki, et al.
Publicado: (2019)

Transcriptomic correlates of neuron electrophysiological diversity
por: Tripathy, Shreejoy J., et al.
Publicado: (2017)

Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte state
por: Paryani, Fahad, et al.
Publicado: (2023)

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development
por: Farhy-Tselnicker, Isabella, et al.
Publicado: (2018)

Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering
por: Thrane, Vinita Rangroo, et al.
Publicado: (2013)

Photo-Induced Oxidative Stress Impairs Mitochondrial Metabolism in Neurons and Astrocytes
por: Berezhnaya, Elena, et al.
Publicado: (2017)

The difficulty to model Huntington’s disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells
por: Le Cann, Kim, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tf5h6vofkknb0ij939nh4cpshn