Geometrical Patterning and Constituent Cell Heterogeneity Facilitate Electrical Conduction Disturbances in a Human Induced Pluripotent Stem Cell-Based Platform: An In vitro Disease Model of Atrial Arrhythmias

Ectopic foci from pulmonary veins (PVs) comprise the main trigger associated with the initiation of atrial fibrillation (AF). An abrupt anatomical narrow-to-wide transition, modeled as in vitro geometrical patterning with similar configuration in the present study, is located at the junction of PVs...

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Detalles Bibliográficos
Autores principales: Nakanishi, Hiroyuki, Lee, Jong-Kook, Miwa, Keiko, Masuyama, Kiyoshi, Yasutake, Hideki, Li, Jun, Tomoyama, Satoki, Honda, Yayoi, Deguchi, Jiro, Tsujimoto, Shinji, Hidaka, Kyoko, Miyagawa, Shigeru, Sawa, Yoshiki, Komuro, Issei, Sakata, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610482/
https://www.ncbi.nlm.nih.gov/pubmed/31316396
http://dx.doi.org/10.3389/fphys.2019.00818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610482/
https://www.ncbi.nlm.nih.gov/pubmed/31316396
http://dx.doi.org/10.3389/fphys.2019.00818

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