Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer’s Disease and CSF Amyloid Biomarkers in APOE ε4 Non-Carriers

It was recently suggested that beta-site amyloid precursor protein (APP)-cleaving enzyme 2 (BACE2) functions as an amyloid beta (Aβ)-degrading enzyme; in addition to its better understood role as an APP secretase. Due to this finding we sought to understand the possible genetic risk contributed by t...

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Detalles Bibliográficos
Autores principales: Huentelman, Matt, De Both, Matthew, Jepsen, Wayne, Piras, Ignazio S., Talboom, Joshua S., Willeman, Mari, Reiman, Eric M., Hardy, John, Myers, Amanda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610620/
https://www.ncbi.nlm.nih.gov/pubmed/31270419
http://dx.doi.org/10.1038/s41598-019-45896-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610620/
https://www.ncbi.nlm.nih.gov/pubmed/31270419
http://dx.doi.org/10.1038/s41598-019-45896-4

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